Atlas of Variant Effects Alliance:
Precision medicine at nucleotide resolution
Art by Uta Mackensen (CC BY-ND) Image Description: Background: A world map and chromosome idiogram. Foreground: People moving amongst and inspecting larger than life Variant Effect Maps of clinically important genes BRCA1, HMBS, MTHFR and TDP-43.
The vision of the Alliance is to create comprehensive variant effect maps for important regions of human and human pathogen genomes that could ultimately assist in the diagnosis, prognosis and treatment of disease. The goal of our Alliance is to bring together data generators, curators and consumers, along with funders and other stakeholders, to set standards, share tools and develop strategy.
By describing the effects of variants in the genome, the atlas will accelerate and empower biological research, drug discovery and medical practice.
Graphic Credits: kjpargeter Freepik, Sayeh Gorjifard and Uta Mackensen
Latest Event
25 March 2026, Melbourne, Australia.
Mutational Scanning Symposium 2026
Event jointly organized by: AVE and St Vincent's Institute of Medical Research
Latest AVE Mention in the News
10 November 2025.
We aim to strike a balance between theoretical, computational, and experimental approaches to ensure comprehensive coverage of the field.
Latest Seminars
3 February 2026.
Yuriy is an Assistant Professor working at the intersection of immunology, genetics and genomics. His group at CCHMC builds new approaches to unlock the mysteries of inflammatory and autoimmune diseases. The research is a mixture of experimental and computational work that generates and analyzes large-scale genomic datasets. Yuriy obtained his PhD at the University of Toronto in the Department of Immunology and completed his postdoctoral training at Brigham and Women’s Hospital in affiliation with Harvard Medical School and the Broad...more3 February 2026.
Stephan Riesenberg is a German biochemist and genome engineer known for developing practical solutions to some of the most persistent limitations of CRISPR-based technologies. He is a Group Leader at the Max Planck Institute for Evolutionary Anthropology in Leipzig, where he develops molecular strategies to control DNA repair outcomes and enable predictable genome modification for research and biomedical applications. He earned his PhD in Biochemistry and later completed an MD-scientist degree at the University of Leipzig. Riesenberg was trained in...moreAVE in Action
Image credit: Ivan Martí
2025 Mutational Scanning Symposium (IBEC Barcelona Spain)
Image credit: Ivan Martí
2025 Mutational Scanning Symposium (IBEC Barcelona Spain)
Broad Mutational Scanning Symposium
Toronto Lab
Clare Turnbull and Shawn Fayer
MAVE workshop
MAVE workshop
Hasan and Marcin Marsh Lab
Cell Factories
Broad Mutational Scanning Symposium
Broad Mutational Scanning Symposium
Broad Mutational Scanning Symposium
Image credit: Greg Moss (Wellcome Sanger Institute)
Larissa Matsuyama, Fernanda Arriaga González and Rebeca Olvera León (SGE team, Welcome Sanger Institute)
