Home Page

Atlas of Variant Effects Alliance : Precision medicine at nucleotide resolution

Atlas of Variant Effects Alliance:
Precision medicine at nucleotide resolution

Atlas of Variant Effects Alliance

Art by Uta Mackensen (CC BY-ND) Image Description: Background: A world map and chromosome idiogram. Foreground: People moving amongst and inspecting larger than life Variant Effect Maps of clinically important genes BRCA1, HMBS, MTHFR and TDP-43.

The vision of the Alliance is to create comprehensive variant effect maps for important regions of human and human pathogen genomes that could ultimately assist in the diagnosis, prognosis and treatment of disease. The goal of our Alliance is to bring together data generators, curators and consumers, along with funders and other stakeholders, to set standards, share tools and develop strategy.

By describing the effects of variants in the genome, the atlas will accelerate and empower biological research, drug discovery and medical practice.

Graphic Credits: kjpargeter Freepik, Sayeh Gorjifard and Uta Mackensen

Join us
The Alliance welcomes individuals from academia, industry, government or other entities anywhere in the world
Variant Effects Seminar Series
In this series, early-career scientists from around the globe share and discuss their research related to interpreting human genetic variation
Mutational Scanning Symposium
8th Annual Mutational Scanning Symposium in Barcelona, Spain

Latest Event

9th Annual Mutational Scanning Symposium 2026

25 March 2026, Melbourne, Australia.

Mutational Scanning Symposium 2026

Event jointly organized by: AVE and St Vincent's Institute of Medical Research

View all Events

Latest AVE Mention in the News

Two Organizers of the Variant Effects Seminars Share Observations and Insights

10 November 2025.

We aim to strike a balance between theoretical, computational, and experimental approaches to ensure comprehensive coverage of the field.

View all News

Latest Seminars

Identifying causal variants with CRISPR editing in primary human cells

3 February 2026.

Yuriy is an Assistant Professor working at the intersection of immunology, genetics and genomics. His group at CCHMC builds new approaches to unlock the mysteries of inflammatory and autoimmune diseases. The research is a mixture of experimental and computational work that generates and analyzes large-scale genomic datasets. Yuriy obtained his PhD at the University of Toronto in the Department of Immunology and completed his postdoctoral training at Brigham and Women’s Hospital in affiliation with Harvard Medical School and the Broad...more

View all Seminars

Efficient CRISPR-mediated generation of genetic variants for functional analysis

3 February 2026.

Stephan Riesenberg is a German biochemist and genome engineer known for developing practical solutions to some of the most persistent limitations of CRISPR-based technologies. He is a Group Leader at the Max Planck Institute for Evolutionary Anthropology in Leipzig, where he develops molecular strategies to control DNA repair outcomes and enable predictable genome modification for research and biomedical applications. He earned his PhD in Biochemistry and later completed an MD-scientist degree at the University of Leipzig. Riesenberg was trained in...more

View all Seminars

AVE in Action