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Workstreams

Alliance Workstreams are responsible for realizing the goals of the Alliance in key areas by setting standards, providing tools and disseminating information.

2025 Workstream Graphic
ets Experimental Technology and Standards (ETS) This workstream facilitates the development, scaling, evaluation, comparison and dissemination of new experimental MAVE methods.
amp Analysis, Modelling and Prediction (AMP) The AMP workstream drives the development and adoption of computational tools and best practices for analyzing and predicting variant effects from MAVEs and computational models to advance mechanistic and clinical insights.
cg ClinGen/AVE Functional Data Working Group This Working Group will focus on approaches for calibration of functional assays for use in variant classification.
dcd Data Coordination and Dissemination (DCD) The Data Coordination and Dissemination (DCD) workstream facilitates the sharing and discoverability of MAVE projects and MAVE data.