10th Annual Mutational Scanning Symposium

Jay Shendure is one of the founding figures of deep mutational scanning and a pioneer in high-throughput methods for variant interpretation. His lab at the University of Washington has produced landmark studies connecting functional variant data to clinical outcomes.

He is the Lead Scientific Director of the Seattle Hub for Synthetic Biology, co-directs the Brotman Baty Institute for Precision Medicine and is a Howard Hughes Medical Institute Investigator. His return to the MSS stage in Seattle — where this symposium began — for its 10th anniversary is a special occasion.

Dr. Adamson is an Associate Professor in the Department of Molecular Biology and the Lewis-Sigler Institute for Integrative Genomics at Princeton University. She trained at MIT, completed her PhD at Harvard Medical School studying DNA repair with Stephen Elledge, and pursued postdoctoral work with Jonathan Weissman at UCSF — supported by a Damon Runyon Cancer Research Foundation fellowship — where she pioneered new approaches for functional genomics in human cells.

Her lab at Princeton continues to develop cutting-edge tools including genetic screening and single-cell RNA-sequencing to study genome editing, DNA repair, and cellular pathway dissection.

David Baker is a Nobel laureate, professor of biochemistry, HHMI investigator, and director of the Institute for Protein Design at the University of Washington. His lab develops software for protein design and uses it to create molecules that address challenges in medicine, technology, and sustainability. Recent work includes the development of machine learning methods for generating functional proteins.

David is also an adjunct professor of genome sciences, bioengineering, chemical engineering, computer science, and physics at the University of Washington. He has published more than 650 scientific papers, been awarded over 100 patents, and co-founded 21 biotechnology companies. More than 100 of his trainees have gone on to independent faculty positions.

He is the recipient of numerous awards, including the 2024 Nobel Prize in Chemistry “for computational protein design.” He is an elected member of the National Academy of Sciences, National Academy of Engineering, and National Academy of Inventors. David was also included on TIME’s inaugural list of the 100 Most Influential People in health.

David received his PhD in biochemistry with Randy Schekman at the University of California, Berkeley, and conducted postdoctoral research in biophysics with David Agard at UCSF.