MAVE educational resources

Thinking about incorporating MAVEs into your work? Here are useful MAVE-relevant reviews.

• Tabet D., Parikh V., Mali P., Roth F.P. & Claussnitzer M. Scalable functional assays for the interpretation of human genetic variation. Annu Rev Genet. 2022.

• Geck R.C., Boyle G., Amorosi C.J., Fowler D.M. & Dunham M.J. Measuring pharmacogene variant function at scale using multiplexed assays. Annu Rev Pharmacol Toxicol. 2022.

• Findlay G.M. Linking genome variants to disease: scalable approaches to test the functional impact of human mutations. Hum Mol Genet. 2021. Kinney J.B. & McCandlish D.M. Massively parallel assays and quantitative sequence-function relationships. Annu Rev Genom Hum Genet. 2019.

• Weile J. & Roth F.P. Multiplexed assays of variant effects contribute to a growing genotype–phenotype atlas. Hum Genet. 2018.

• Starita L.M., Ahituv N., Dunham M.J., Kitzman J.O., Roth F.P., Seelig G., Shendure J. & Fowler D.M. Variant interpretation: functional assays to the rescue. Am J Hum Genet. 2017.

• Gasperini M., Starita L. & Shendure J. The power of multiplexed functional assays of genetic variants. Nat Protoc. 2016.

Technology and methods development manuscripts

Designing a MAVE? >>Follow this link<< to view granular reviews and seminal papers relevant to methods at each stage of the MAVE development process.