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About Us

About Us

Advancing the promise of the Human Genome Project by interpreting the landscape of human genetic variation

For the Public

Information about AVE for the public

Researchers & Clinicians

Information about AVE for researchers and clinicians

People

Leadership
Executive Committee, Administrative Support, Alumni
Alliance members
We have over 700 members from 50 nations in the Alliance. 
VESS Organizing Committee
VESS Organizing Committee at AVE
Workstream & Committee Chairs
Workstream & Committee Chairs at AVE

News & Events

Upcoming events
Events related to Variant Effect
Mutational Scanning Symposium
We hope you can join us for the next Annual Mutational Scanning Symposium
News
AVE mentioned in recent articles and in the news
Seminar Series
Early-career scientists from around the globe share and discuss their research

Watch & Listen

Podcast

MAVE Rare Disease Podcast

Youtube

Watch us on Youtube

Organization & Governance

Annual Reports

We’re excited to share with you our annual reports highlighting Alliance activities

Code of Conduct

A diverse and inclusive community is absolutely essential to the achievement of our shared scientific goals

Organization & Governance

Internationally recognized organization founded in 2020

Strategic Plan

Understanding genetic variation at nucleotide resolution 

Timeline

Atlas of Variant Effects Timeline

Workstreams

Setting standards, providing tools and disseminating information

Interact with us

Contact Us

Ask a question or to learn more about our mission and work

Suggest a speaker

Nominations will be considered on a rolling basis until all program slots have been filled. Self-nominations are welcome and encouraged.  

Donate

Your generous contribution supports our mission and helps to support (and grow) Alliance research programs

Social media

Bluesky

Atlas of Variant Effects Alliance on Bluesky

Linkedin

Atlas of Variant Effects Alliance on Linkedin

Youtube

Atlas of Variant Effects Alliance on Youtube

Resources & Tools

Article Collection

Collection published on July 3rd, 2023 in Genome Biology

Clinical Application

Guidance on how to use Functional Evidence in your Clinical Practice

MAVE Analysis Tools

High-throughput methods employed to investigate the impact of genetic variations in proteins or nucleic acids on their functionality

MAVE Resources

This technique harnesses the power of next-gen sequencing and yields large-scale data sets

MaveDB

A public repository for datasets from Multiplexed Assays of Variant Effect, such as those generated by deep mutational scanning  or massively parallel reporter assay  experiments

MaveRegistry

A collaborative resource and platform for sharing progress on Multiplexed Assays of Variant Effect

Publications

AVE mentioned or cited in Scientific Publications

Resources/Training

Check out the resources  to get started

Variant Effect Predictors

Computational approaches can leverage variant effect data for functional interpretation