Thea did her PhD research in the Lindorff-Larsen lab at the University of Copenhagen. Her research focuses on explaining and predicting which missense variants are likely to change the cellular abundance of a protein. Concretely, she combines data from abundance MAVEs (VAMP-seq) on several proteins to study the cellular abundance of variants across protein backgrounds. Thea's talk will focus on what can be learned from such large-scale analyses, discuss why it can be difficult to combine variant scores from several MAVEs to supervise variant effect predictors, and finally present a potential solution to address some of these challenges.