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6th annual Mutational Scanning Symposium (2023)
5th annual Mutational Scanning Symposium (2022)
4th annual Mutational Scanning Symposium (2021)
Mutational Scanning Symposium 2023
Bringing function to the genome
When: July 13 &14, 2023
Where: Wellcome Genome Campus, UK and Virtual
Program: Can be found HERE
Event Hashtag: #VariantEffect23
About: Mutational scanning technologies and Multiplex Assays of Variant Effects (MAVEs) are key to variant interpretation and transform our understanding of the human genome.
At the 6th annual meeting of the ‘Mutational Scanning Symposium’, experts in the fields of functional genomics, protein science, precision medicine, variant interpretation, and computational genetics came from around the world to meet, present their work, discuss new methods and provide insights on the future of this science.
The conference was a two-day hybrid meeting with onsite or virtual attendance. Discussions centered on a variety of exciting topics, including computational variant effect prediction, saturation mutagenesis, sequence/structure/function relationships, high throughput assays and protein engineering. There were focused discussions how to apply functional data to clinical practice along with conversations about emerging technologies for functional assays.
Speakers included:
Frederick Roth University of Toronto, Canada (KEYNOTE)
Leslie G. Biesecker NIH-National Human Genome Research Institute, USA
Erika Alden DeBenedictis The Francis Crick Institute, UK
Liselot Dewachter KU Leuven, Belgium
Mafalda Dias Centre for Genomic Regulation, Spain
Diane Dickel Octant Bio, USA
Greg Findlay The Francis Crick Institute, UK
Irene Gallego Romero University of Melbourne , Australia
Isaac Jia Greater Bay Area Institute of Precision Medicine, China
Ben Lehner Wellcome Sanger Institute, UK
Victoria Parikh Stanford University, USA
Gabriel Rocklin Northwestern University, USA
Raghavan Varadarajan Indian Institute of Science, India
You can find the final programme for the conference >>> HERE
Thank you to this year’s event sponsors!
By the Numbers summary of the 2023 Mutational Scanning Symposium . Graphics credit: Freepik and Alex Cagan
Pre and Post Event Press
Building an atlas of gene variants to understand health and disease - Wellcome Sanger Institute Blog - Summary from the 6th Annual Mutational Scanning Symposium
Following Up on MSS 2023: Perspectives from Two Participants -Q&A with Drs. Raghavan Varadarajan and Yann Ilboudo.
Exploring variant effects to advance precision medicine - Post event synopsis by Dr Sounak Sahu
Planning committee members and organizers:
David Adams (he/him) Wellcome Sanger Institute, UK
Matthew Hurles (he/him) Wellcome Sanger Institute, UK
Lara Muffley (she/her) University of Washington, USA
Lea Starita (she/her) University of Washington, USA
Clare Turnbull (she/her) The Institute of Cancer Research, UK
Amanda Fletcher (she/her) Wellcome Connecting Science Conference & Events Organiser
Nagehan Ramazanoglu Bahadir (she/her) Wellcome Connecting Science Scientific Programme Officer
‘Clinical Application of MAVE Data’ workshop
One day before the symposium, on the 12th of July, an in person workshop (jointly hosted by the scientific committee of the Curating the Clinical Genome and the Mutational Scanning Symposium) was held to discuss the potential use of mutational scanning data in variant classification in clinical practice. Workshop report: the clinical application of data from multiplex assays of variant effect (MAVEs).
Clinical Application of MAVE Data workshop participants
Follow us on Twitter @varianteffects. Event Hashtag: #VariantEffect23