Gene editing innovation to improve genome variant exploration
Date: 14 August 2024
Author: Greg Moss, Wellcome Sanger Institute
The haploid cell line HAP1 LIG4 KO has been modified to be highly efficient for CRISPR-based experiments by researchers at the Wellcome Sanger Institute. Available via Revvity to both academic and industry researchers, the cell line has been used to greatly increase gene editing rates in Saturation Genome Editing (SGE) experiments to assess variant effects at scale, with many other applications possible.