Understanding the functional consequences of every single mutation in Your Favourite Gene
Date: 1 September 2021
Author: Dr Alan Rubin
A central problem in genomic medicine is understanding the effects of individual DNA variants. Although their function can be explored in the lab, assessing variants individually is both time and resource intensive. Multiplexed Assays of Variant Effect (MAVEs) are a family of experimental techniques that allow researchers to measure all possible variants of a gene or other functional element at once.