Bridge RNAs direct programmable recombination of target and donor DNA

Matt Durrant received his PhD from Stanford University in 2020, working in the labs of Ami Bhatt and Stephen Montgomery on computationally characterizing mobile genetic elements. He continued on to a short postdoc in the lab of Patrick Hsu at UC Berkeley, where he discovered and characterized new large serine recombinases (LSRs) that could efficiently integrate DNA cargos into the genomes of human cells. He then transitioned to a senior scientist position in the Hsu Lab at the Arc Institute, where he continues his work with a focus on programmable recombinases and genome design.