Mutational scanning to understand ligand efficacy and potency in GPCRs

Matthew is a PhD student working with Willow Coyote-Maestas and Aashish Manglik at the University of California, San Francisco. In the lab, Matt develops high-throughput assays to enable mutational scanning of many G protein-coupled receptor phenotypes. These approaches are applied to diverse receptor systems to better understand receptor biogenesis, ligand recognition, and signal transduction.