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Mutating the Human Domainome

Toni Beltran (he/him)

Center for Genomic Regulation (CRG)

Presentation Date: 4 February 2025

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I'm a Postdoc at Lehner lab at CRG Barcelona interested in understanding the language of proteins - how their sequence determines their biochemical properties and functions. In my postdoc I have focused on multiplexed deep mutational scans of human protein domains, and on combining DMS with multiple molecular readouts to understand allosteric communication in kinases. Before joining the variant bio world I worked on quantifying the dynamics and stability of heritable epigenetic states by sequencing many generations of isogenic worms as a PhD student at the MRC-LMS (Imperial College London). I enjoy the combination of large-scale experimentation and computational analysis to understand fundamental biological questions.

Social: @mutatoni