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ETS Strategic ROADMAP

ABOUT: This workstream facilitates the development, scaling, evaluation, comparison and dissemination of new MAVE methods. Members of this team:

• Develop measures by which to evaluate experimental methods, e.g., what information should go on a ‘report card’ for a mutagenized library, a transfection step, a flow-sorting experiment.
• Develop an information resource for alternative technologies with protocols, tips, caveats.
• Design physical standards (mutagenized libraries, barcode libraries, gRNA pools) that can enable controlled comparison of other tech steps, and strategies for sharing physical standards across groups.

Workstream lead(s):

Andrew Glazer (VUMC) and Alex Nguyễn Ba (University of Toronto)

Contributors/ Members:

Benedetta Bolognesi  (IBEC)
Michael Böttcher (Martin Luther University)
Melina Claussnitzer (Harvard, Broad Institute)
Sven Diederichs (DKFZ | University Hospital Freiburg)
Guillaume Diss (Friedrich Miescher Institute)
Greg Findlay (Francis Crick Institute)
Jacob Kitzman (University of Michigan)
Andrea Martella (AstraZeneca)
Kenneth Matreyek (Case Western)
Daniel O’Neill  (AstraZeneca)
Victoria Nicole Parikh (Stanford University)
Fritz Roth (University of Toronto)
Daniel Tabet (University of Toronto)
Valeria Vasta (University of Washington)