Guide
Experimental Technology and Standards (ETS)
This workstream facilitates the development, scaling, evaluation, comparison and dissemination of new experimental MAVE methods.
Members of this workstream are working to:
- Develop an information resource (or directory of information resources) covering alternative technologies with protocols, tips, caveats (working with AMP on analysis aspects, DCD on disseminating resource)
- Develop measures by which to evaluate individual experimental steps, e.g., what information should go on a ‘report card’ for a mutagenized library (both at amplicon stage and cellular library stage), a transfection step, a flow-sorting experiment.
- Co-Develop measures of overall quality of a map or library, e.g., accuracy (according to control labeled e.g. pathogenic vs benign, aggregating vs not), reproducibility, dynamic range, resolution.
- Produce periodic review papers with specific guidelines/recommendations to achieve these goals
Alex Nguyễn Ba
University of Toronto
Dr. Nguyen Ba is an Assistant Professor at the University of Toronto (UofT). He earned his PhD in computational biology at UofT and did his postdoctoral training on high-throughput genetics and synthetic biology with Michael Desai at Harvard University. His lab focuses on fundamental questions on the genotype-phenotype map and on humanized yeast models for variant effect mapping.
Sven Diederichs
DKFZ | University Hospital Freiburg
Dr. Sven Diederichs is a Professor of Cancer Research at the University Medical Center Freiburg and the German Cancer Consortium DKTK. His research focuses on high throughput functional cancer genomics of the Fibroblast Growth Factor Receptors to increase the number of mutations informative for clinical decisions. Also, he studies non-canonical types of mutations like synonymous mutations or nonstop or stop-loss mutations. His previous expertise also covers long non-coding RNAs and RNA-binding proteins.
Benedetta Bolognesi (IBEC)
Michael Böttcher (Martin Luther University)
Sven Diederichs (DKFZ | University Hospital Freiburg)
Andrew Glazer (VUMC)
Andrea Martella (AstraZeneca)
Kenneth Matreyek (Case Western)
Daniel O’Neill (AstraZeneca)
Become a Member
The Alliance welcomes individuals from academia, industry, government or other entities anywhere in the world.
This workstream facilitates the development, scaling, evaluation, comparison and dissemination of new experimental MAVE methods.