Biography

Thea did her PhD research in the Lindorff-Larsen lab at the University of Copenhagen and is currently a postdoc with Joe Greener at the MRC Laboratory of Molecular Biology. During her PhD, Thea researched how missense variation affects the cellular abundance of a protein. Concretely, she combined data from abundance MAVEs (VAMP-seq) on several proteins to study the cellular abundance of variants across protein backgrounds. Thea's talk will focus on what can be learned from such large-scale analyses and why it can be difficult to combine variant scores from several MAVEs to supervise variant effect predictors.

Seminars

Towards predictive models of variant effects on protein abundance (by learning from mutational scanning on different proteins)

Social Links

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