Towards predictive models of variant effects on protein abundance (by learning from mutational scanning on different proteins)

Thea did her PhD research in the Lindorff-Larsen lab at the University of Copenhagen and is currently a postdoc with Joe Greener at the MRC Laboratory of Molecular Biology. During her PhD, Thea researched how missense variation affects the cellular abundance of a protein. Concretely, she combined data from abundance MAVEs (VAMP-seq) on several proteins to study the cellular abundance of variants across protein backgrounds. Thea's talk will focus on what can be learned from such large-scale analyses and why it can be difficult to combine variant scores from several MAVEs to supervise variant effect predictors.